High-quality ontologies are critical to ontology-based applications, such as natural language understanding and information extraction, but logical conflicts naturally occur in the lifecycle of ontology development.To deal with such conflicts, conflict detection and ontology repair become two critical tasks, and we focus on repairing ontologies.Mos
Integrating Conformational Dynamics and Perturbation-Based Network Modeling for Mutational Profiling of Binding and Allostery in the SARS-CoV-2 Spike Variant Complexes with Antibodies: Balancing Local and Global Determinants of Mutational Escape Mechanisms
In this study, we combined all-atom MD simulations, the ensemble-based mutational scanning of protein stability and binding, and perturbation-based network profiling of allosteric interactions in the SARS-CoV-2 spike complexes with a panel of cross-reactive and ultra-potent single antibodies (B1-182.1 and A23-58.1) as well as antibody combinations
Strengthening, rehabilitation and widening of the existing arch bridge on national route 7 over the Olifants River, South Africa
This paper describes the rehabilitation of the existing bridge over the Olifants River.The bridge is on National Route 7 near Klawer and dates back to 1957.The defining feature of Matchy Match this elegant bridge is a concrete arch spanning 92.7 m.The existing bridge displayed extensive cracking, failed expansion joints and spall damage to beam sof
Preschoolers prefer to learn causal information
Young children, in general, appear to have a strong drive to explore the environment Salad Bars in ways that reveal its underlying causal structure.But are they really attuned specifically to casual information in this quest for understanding, or do they show equal interest in other types of non-obvious information about the world? To answer this q
Design and application of a multimodality-compatible 1Tx/6Rx RF coil for monkey brain MRI at 7T
Objective: Blood-oxygen-level-dependent functional MRI allows to investigte neural activities and connectivity.While the non-human primate plays an essential role in neuroscience research, multimodal methods combining functional MRI with other neuroimaging and neuromodulation enable us to understand the brain network at multiple scales.Approach: In